What is the Best 5-Day Wyoming road trip itinerary?

The best 5-day Wyoming road trip from Devils Tower to Cheyenne takes you through Buffalo, Casper, Saratoga, and Laramie. This route blends iconic landmarks, scenic drives, Western history, hot springs and outdoor adventure for a well-rounded Wyoming experience.

Devils Tower National Monument is celebrating its 120th anniversary of being the first national monument in 2026.

Day 1: Devils Tower to Buffalo - Scenic Start & Historic Stay

Start your Wyoming road trip at one of the most recognizable landmarks in the American West.

Top Things to Do

  • Explore Devils Tower National Monument, America’s first national monument
  • Go hiking around the base trail or enjoy stargazing
  • Learn about the cultural significance to Northern Plains tribes

Where to Eat

  • Cowboy Bar & Grill – classic Wyoming bar and grill with flexible hours
  • Pie Zanos – local favorite for wood-fired pizza and Italian dishes (check hours)

Where to Stay

Crazy Woman Canyon

Day 2: Buffalo to Casper - Scenic Drives & Western Culture

This day combines one of Wyoming’s most scenic drives with authentic Western experiences.

Top Things to Do

Where to Eat

Where to Stay

Day 3: Casper to Saratoga - Outdoor Adventure & Hot Springs

Experience Wyoming’s outdoor beauty and unwind in natural hot springs.

Top Things to Do

  • Ride with Historic Trails West for a cowboy-style experience
  • Hike at Mirror Lake with scenic mountain views in the Snowy Range
  • Relax at the hobo pools, a hot spring in Saratoga, free to the public

Where to Eat

Where to Stay

The Wyoming Territorial Prison in Laramie

Day 4: Saratoga to Cheyenne (via Laramie) - History & Downtown Stops

Explore Wyoming’s rich history and vibrant small towns.

Top Things to Do

Where to Eat

Where to Stay

Day 5: Best Things to Do in Cheyenne, Wyoming

Wrap up your road trip with classic Cheyenne experiences.

Top Things to Do

Where to Eat

How Long Does It Take to Drive from Devils Tower to Cheyenne?

Driving from Devils Tower to Cheyenne takes approximately 6 to 7 hours without stops. Spreading the trip across 5 days allows time to explore attractions, enjoy scenic routes and experience local culture.

Best Time of Year for a Wyoming Road Trip

The best time for this Wyoming road trip is late spring through early fall (May to October). During this time, roads are clear, weather is mild and outdoor activities are fully accessible.

Tips for Planning a Wyoming Road Trip

  • Plan fuel stops in advance due to long rural stretches
  • Check weather conditions, especially in mountain areas
  • Pack layers for changing temperatures
  • Book lodging early during peak travel season

Frequently Asked Questions 

Is Devils Tower worth visiting?

Yes, Devils Tower is one of Wyoming’s most iconic landmarks, offering hiking, climbing and deep cultural significance.

What is there to do in Casper, Wyoming?

Casper offers Western shopping, distilleries, outdoor recreation and historic trail experiences.

Where are the best hot springs in Wyoming?

Saratoga Hot Springs is one of the most popular and accessible hot springs destinations in Wyoming.

How many days do you need in Wyoming?

A 5 to 7-day trip is ideal to explore Wyoming’s top attractions at a relaxed pace.